Guy Hanke
“I know of nothing sublime that is not some modification of power” Edmund Burke
2023
2022
2021
Richardson KH, Wright JJ, Šimėnas M, Thiemann J, Esteves AM, McGuire G, Myers WK, Morton JJL, Hippler M, Nowaczyk MM, Hanke GT (joint corresponding), Roessler MM (2021) Functional basis of electron transport within photosynthetic complex 1. Nat Commun 12:5387. DOI: 10.1038/s41467-021-25527-1
Sarewicz M, Pintscher S, Pietras R, Borek A, Bujnowicz Ł, Hanke G, Cramer WA, Finazzi G, Osyczka A (2021) Catalytic Reactions and Energy Conservation in the Cytochrome bc1 and b6f Complexes of Energy-Transducing Membranes. Chem Rev. 121:2020-2108. DOI: 10.1021/acs.chemrev.0c00712
Kramer M, Rodriguez-Heredia M, Saccon F, Mosebach L, Twachtmann M, Krieger-Liszkay A, Duffy C, Knell RJ, Finazzi G, Hanke GT (2021) Regulation of photosynthetic electron flow on dark to light transition by ferredoxin:NADP(H) oxidoreductase interactions. Elife. 10:e56088. DOI: 10.7554/eLife.56088.
Shimakawa G, Hanawa H, Wada S, Hanke GT, Matsuda Y, Miyake C. (2021) Front Plant Sci. 12:668805. DOI: 10.3389/fpls.2021.668805
Lea-Smith DJ, Hanke GT (2021). Electron transport in cyanobacteria and its potential in bioproduction. Chapter in Cyanobacteria Biotechnology (Wiley-VCH GmbH). 33-63.
Since 2015
Mellor SB, Vinde MH, Nielsen AZ, Hanke GT, Abdiaziz K, Roessler MM, Burow M, Motawia MS, Møller BL, Jensen PE. (2019) Defining optimal electron transfer partners for light-driven cytochrome P450 reactions. Metab Eng. 55:33-43
Herbst J, Girke A, Hajirezaei MR, Hanke G and Grimm B (2018) Potential roles of YCF54 and ferredoxin‐NADPH reductase for magnesium protoporphyrin monomethylester cyclase. Plant J. 94(3):485-496
Schorsch M, Kramer M, Goss T, Eisenhut M, Robinson N, Osman D, Wilde A, Sadaf S, Brückler H, Walder L, Scheibe R, Hase T, Hanke GT. (2018) A unique ferredoxin acts as a player in the low-iron response of photosynthetic organisms. Proc Natl Acad Sci U S A. 115(51):E12111-E12120. doi: 10.1073/pnas.1810379115.
Hanke GT and Scheibe RS (2018) The contribution of electron transfer after photosystem I to balancing photosynthesis. Photosynthesis and Bioenergetics Eds. Barber J and Ruban A. 277-304
Hanke GT (2017) preface: Ferredoxin. Guest Editors introduction to the special issue. Photosynth Res 134:233–234
Shinohara M, Kurisu G, Hanke G, Bowsher C, Hase T, Kimata Ariga, Y. (2017) Structural basis for the isotype-specific interactions of ferredoxin and ferredoxin: NADP+ oxidoreductase: an evolutionary switch between photosynthetic and heterotrophic assimilation. Photosyn Res 134(3):281-289
Mosebach L, Heilmann C, Mutoh R, Gäbelein P, Steinbeck J, Happe T, Ikegami T, Hanke G, Kurisu G, Hippler M (2017) Association of Ferredoxin:NADP+ oxidoreductase with the photosynthetic apparatus modulates electron transfer in Chlamydomonas reinhardtii. Photosynth Res. 134(3):291-306
Kozuleva M, Goss T, Twachtmann M, Rudi K, Trapka J, Selinski J, Ivanov B, Garapathi P, Steinhoff HJ, Hase T, Scheibe R, Klare JP, Hanke G (2016) Ferredoxin:NADP(H) oxidoreductase abundance and location influences redox poise and stress tolerance. Plant Physiol. 172:1480-1493
Hachiya T, Ueda N, Kitagawa M, Hanke G, Suzuki A, Hase T, Sakakibara H (2016) Arabidopsis Root-Type Ferredoxin:NADP(H) Oxidoreductase 2 Is Involved in Detoxification of Nitrite in Roots. Plant Cell Physiol. 57:2440-2450
Kim JY, Kinoshita M, Kume S, Hanke GT, Sugiki T, Ladbury JE, Kojima C, Ikegami T, Kurisu G, Goto Y, Hase T, Lee YH (2016) Noncovalent forces tune the electron transfer complex between ferredoxin and sulfite reductase to optimize enzymatic activity. Biochem J. 473(21):3837-3854
Earlier
Lehtimäki N, Koskela MM, Dahlström KM, Pakula E, Lintala M, Scholz M, Hippler M, Hanke GT, Rokka A, Battchikova N,Salminen TA, Mulo P (2014) Post-translational modifications of ferredoxin-NADP+ oxidoreductase in Arabidopsis thaliana chloroplasts. Plant Physiol 166, 1764-76
Goss T, Hanke GT (2014) The end of the line: can ferredoxin and ferredoxin NADP(H) oxidoreductase determine the fate of photosynthetic electrons? Curr Protein Pept Sci 15, 385-393
Selinski J, König N, Wellmeyer B, Hanke GT, Linke V, Neuhaus HE, Scheibe R (2014) The plastid-localized NAD-dependent malate dehydrogenase is crucial for energy homeostasis in developing Arabidopsis thaliana seeds. Mol Plant 7, 170-186
Blanco NE, Ceccoli RD, Dalla Vía MV, Voss I, Segretin ME, Bravo-Almonacid FF, Melzer M, Hajirezaei M, Scheibe R, Hanke GT (2013) Expression of the minor isoform pea ferredoxin in tobacco alters photosynthetic electron partitioning and enhances cyclic electron flow. Plant Phys 161, 866-879
Busch KB, Deckers-Hebestreit G, Hanke GT, Mulkidjanian AY (2013) Dynamics of bioenergetic membranes. Biol Chem 394, 163-188
Zachgo S, Hanke GT, Scheibe R (2013) Plant Cell Microcompartments, a signaling perspective. Biol Chem 394, 203-216
Hanke GT, Mulo P (2013) Plant type ferredoxins and ferredoxin-dependent metabolism. Plant Cell Environ. 36, 1071-1084
Twachtmann M, Altmann B, Muraki N, Okutani S, Voss I, Kurisu G, Hase T, Hanke GT (2012) N-terminal structure of ferredoxin:NADP+ reductase determines recruitment into different thylakoid membrane complexes. Plant Cell 24, 2979-2991
Ceccoli RD, Blanco NE, Segertin ME, Hanke GT, Scheibe RS, Hajirezaei MR, Bravo-Almonacid FF, Carrillo N (2012) Flavodoxin displays dose-dependent effects on photosynthesis and stress tolerance when expressed in transgenic tobacco plants. Planta 236, 1447-1458
Voss I, Goss T, Murozuka E, Altmann B, McLean KJ, Rigby SEJ, Munro A, Scheibe R, Hase T, Hanke GT (2011) FdC1, a novel ferredoxin protein capable of alternative electron partitioning, increases in conditions of acceptor limitation at PSI. J Biol Chem 286, 50-59
Bowsher CG, Eyres LM, Gummadova JO, Hothi P, McLean KJ, Munro AW, Scrutton NS, Hanke GT, Sakakibara Y, Hase T (2011) Identification of N-terminal regions of wheat leaf ferredoxin NADP+ oxidoreductase important for interaction with ferredoxin. Biochemistry-US 50, 1778-1787
Hanke GT, Satomi Y, Shinmura K, Takao T, Hase T (2011) A screen for potential ferredoxin electron transfer partners uncovers new, redox dependent interactions. BBA-Proteins Proteom 1814, 366-374
Hanke GT, Holtgrefe S, König N, Strodkötter I, Voss I, and Scheibe R (2009) Use of transgenic plants to uncover strategies for maintenance of homeostasis during photosynthesis. Adv Bot Res 52, 209-251
Hanke GT, and Hase T. (2008) Variable photosynthetic roles of two leaf-type ferredoxins in Arabidopsis, as revealed by RNA interference. Photochem Photobiol 84, 1302-1309
Hanke GT, Endo T, Sato F, Hase T (2008) Altered photosynthetic electron channeling into cyclic electron flow and nitrite assimilation in a mutant of ferredoxin:NADP(H) reductase. Plant Cell Environ 31, 1017-1028
Gummadova JO, Fletcher GJ, Moolna A, Hanke GT, Hase T, Bowsher CG (2007) Expression of multiple forms of ferredoxin NADP+ oxidoreductase in wheat leaves. J Ex Bot. 58, 3971-3985
Bowsher CG, Lacey AE, Hanke GT, Clarkson DT, Saker LR, Stulen I, Emes MJ (2007) The effect of Glc6P uptake and its subsequent oxidation within pea root plastids on nitrite reduction and glutamate synthesis. J Ex Bot 58, 1109 – 1118
Gou P, Hanke GT, Kimata-Ariga Y, Standley D, Kubo A, Taniguchi I, Nakamura H, Hase T (2006) Higher order structure contributes to specific differences in redox potential and electron transfer efficiency of root and leaf ferredoxins. Biochem
45, 14389-14396
Okutani S, Hanke GT, Satomi T, Takao T, Kurisu G, Suzuki A, Hase T (2005) Three maize leaf ferredoxin:NADP(H) oxidoreductases vary in sub-chloroplast location, expression, and interaction with ferredoxin. Plant Physiol 139, 1451-1459
Hanke GT, Okutani S, Satomi Y, Takao T, Suzuki A, Hase T (2005) Multiple isoproteins of FNR in Arabidopsis: evidence for different contributions to chloroplast function and nitrogen assimilation. Plant Cell Environ 28. 1146-1157
Kurisu G, Nishiyama D, Kusunoki M, Fujikawa S, Katoh M, Hanke GT, Hase T, Teshima K (2005) A structural basis of Equisetum arvense Ferredoxin Isoform II producing an alternative electron transfer with ferredoxin-NADP+ reductase. J Biol Chem 280, 2275-2281
Hanke GT, Kurisu G, Kusunoki M, Hase T (2004) Fd : FNR electron transfer complexes: evolutionary refinement of structural interactions. Photosynth Res 81, 317-327
Hanke GT, Kimata-Ariga Y, Taniguchi I, Hase T (2004) A post genomic characterization of Arabidopsis ferredoxins. Plant Physiol. 134, 255-264
Nakayama M, Hanke GT, Hase T (2003) Ferredoxin-mediating regulation of redox metabolisms in plastids. Protein, Nucleic acid and Enzyme. 48, 2138-2144 (Japanese)
Hanke GT, Northrop FD, Devine GR, Bothwell JH, Davis JM (2001) Chloride channel antagonists perturb growth and morphology of Neurospora crassa. FEMS Microbiol Lett 201, 243-247
Hanke GT, Bowsher CG, Jones M, Tetlow I, Emes MJ (1999) Proteoliposomes and plant transport proteins. J Exp Bot 50, 1715-1726
In 2015 I was appointed to a Senior Lecturer position at Queen Mary College. Now we have a small group pursuing the same research aims. There were two main reasons to take the position: Firstly, I was excited to work in an environment with a group of dynamic researchers in photosynthesis, and secondly our imaging work at Osnabrueck had pointed us in the direction of electron microscopy, for which Queen Mary, and the London Colleges in general are very well equiped.
After some collaborative work, I was invited to a position in the laboratory of Professor Renate Scheibe. Her primary research interest is the dissipation of excess electrons, and it was an exciting chance to combine this with my focus on the supply of electrons to different areas of metabolism. Since moving to Osnabrueck I have developed an independent research group, collaborating to combine the genetic and immunological and biochemical tools I generated in Osaka, with more imaging, biophysical and 'omics approaches. Based on this work I completed my Habilitation in July 2013.
Following a short post-Doc at the University of Cambridge, UK, I took a Japanese Society for the Promotion of Science (JSPS) fellowship to work in the lab of Professor Toshiharu Hase, at the Institute for Protein Research, Osaka University, Japan. For more information about this great program, you can find more details here. I stayed for almost 8 years as a post-Doc and Assistant Professor, and this was a formative time in my research. Under Professor Hase's guidance I became fascinated by redox metabolism in plastids, and in particular how the flow of electrons into different areas of metabolism is controled.
University of Manchester, UK (website)
During my PhD in the labs of Dr Caroline Bowsher and Professor Mike
Emes I developed a general interest in basic plant metabolism, and
in particular in how the provision of energy to this metabolism is
controlled. I also became aware of how important basic
research on crop plants is for our future attempts to feed people
in the face of decreasing agricultural resources.
